Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_0712Hemoglobin-binding protein; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake. (1084 aa)    
Predicted Functional Partners:
amiB
N-acetylmuramoyl-L-alanine amidase, putative; Cell-wall hydrolase involved in septum cleavage during cell division; Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family.
  
 0.731
ftsA
Cell division protein (ftsA); Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.
   
 
 0.632
iga
Immunoglobin A1 protease (iga1); Virulence factor; cleaves host immunoglobulin A producing intact Fc and Fab fragments.
  
   
 0.629
HI_1410
Predicted coding region HI1410; Hypothetical protein; identified by GeneMark; putative.
 
    0.593
tonB
tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.
  
   0.590
HI_1058
Predicted coding region HI1058; Hypothetical protein; identified by GeneMark; putative.
  
     0.536
HI_1054
Conserved hypothetical protein; Similar to PID:1381738 percent identity: 92.49; identified by sequence similarity; putative.
  
     0.533
HI_1055
Predicted coding region HI1055; Hypothetical protein; identified by GeneMark; putative.
  
     0.532
ftsQ
Cell division protein (ftsQ); Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly.
    
 
 0.488
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
 
  
 0.472
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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