Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
yihIConserved hypothetical protein; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (186 aa)    
Predicted Functional Partners:
HI_0725
Conserved hypothetical protein; Similar to PID:1685094 percent identity: 47.62; identified by sequence similarity; putative.
 
     0.940
HI_1205
Conserved hypothetical protein; Similar to GB:U00096 PID:1788632 GB:U00096 PID:1788632 percent identity: 45.45; identified by sequence similarity; putative.
  
   
 0.776
rraB
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.770
rseA
sigma-E factor negative regulatory protein (mclA); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytopl [...]
  
     0.768
lptC
Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA.
  
     0.768
seqA
seqA protein (seqA); Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.766
nlpI
Conserved hypothetical protein; May be involved in cell division.
  
     0.760
HI_0841
Conserved hypothetical protein; Similar to SP:P33922 PID:453987 GB:U00096 PID:1788515 percent identity: 41.57; identified by sequence similarity; putative; To E.coli YejM.
  
     0.753
HI_0028
Conserved hypothetical protein; Similar to GB:L07636 SP:P30977 PID:146621 GB:U00096 PID:1778548 percent identity: 50.59; identified by sequence similarity; putative; Belongs to the UPF0250 family.
  
     0.751
lapA
Conserved hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.739
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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