Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
narPNitrate/nitrite response regulator protein (narP); Could activate the expression of a formate dehydrogenase operon and could repress the transcription of the fumarate reductase (frdABCD) operon. (208 aa)    
Predicted Functional Partners:
narQ
Nitrate/nitrite sensor protein (narQ); Probable member of a two-component regulatory system. It is not known what protein it phosphorylates and in which regulatory pathway it acts, as the narL and other nar genes do not exist in H.influenzae.
 
 0.997
qseC
Sensor protein (ygiY); Member of a two-component regulatory system QseB/QseC. May activate QseB by phosphorylation (By similarity).
 
 0.814
infB
Translation initiation factor 2 (infB); One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
    
 
 0.759
phoR
Phosphate regulon sensor protein (phoR); Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals (By similarity).
 
 
 0.736
HI_1651
Predicted coding region HI1651; Hypothetical protein; identified by GeneMark; putative.
   
 0.688
arcA
Aerobic respiration control protein ARCA (arcA); Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions (By similarity).
  
 0.558
HI_1458
Predicted coding region HI1458; Hypothetical protein; identified by GeneMark; putative.
   
 0.550
rpoD
RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
    
 
 0.539
cpxR
Response regulator (cpxR); Member of a two-component regulatory system.
  
 0.526
uspE
Conserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
   
  
 0.524
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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