Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
tpxThiol peroxidase (tpx); Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (165 aa)    
Predicted Functional Partners:
sodA
Superoxide dismutase (sodA); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.669
gor
Glutathione reductase (gor); Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
   
  
 0.610
msrAB
Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
  
  
 0.609
trxB
Thioredoxin reductase (trxB); Similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096 percent identity: 75.95; identified by sequence similarity; putative.
  
  
 0.556
ompA
Outer membrane protein P5 (ompA); With TolR probably plays a role in maintaining the position of the peptidoglycan cell wall in the periplasm. Acts as a porin with low permeability that allows slow penetration of small solutes; an internal gate slows down solute passage; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. OmpA family.
   
  
 0.468
fur
Ferric uptake regulation protein (fur); Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes.
   
  
 0.455
HI_1430
Short chain dehydrogenase/reductase; Similar to GB:U00096 PID:1787820 percent identity: 58.13; identified by sequence similarity; putative; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
   
    0.447
rlpA
Lipoprotein, putative; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.
      
 0.425
yfiA
Sigma(54) modulation protein, putative; During stationary phase, prevents 70S dimer formation, probably in order to regulate translation efficiency during transition between the exponential and the stationary phases. In addition, during environmental stress such as cold shock or excessive cell density at stationary phase, stabilizes the 70S ribosome against dissociation, inhibits translation initiation and increase translation accuracy. When normal growth conditions are restored, is quickly released from the ribosome (By similarity); Belongs to the HPF/YfiA ribosome-associated protein [...]
   
    0.409
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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