STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HI_0840Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family. (72 aa)    
Predicted Functional Partners:
HI_0841
Conserved hypothetical protein; Similar to SP:P33922 PID:453987 GB:U00096 PID:1788515 percent identity: 41.57; identified by sequence similarity; putative; To E.coli YejM.
 
  
 0.905
HI_0839
Conserved hypothetical protein; Similar to SP:P33920 PID:405914 GB:U00096 PID:1788513 percent identity: 52.38; identified by sequence similarity; putative.
 
   
 0.791
seqA
seqA protein (seqA); Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.773
rseA
sigma-E factor negative regulatory protein (mclA); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytopl [...]
  
     0.755
rraB
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.746
fadR
Fatty acid metabolism regulator protein (fadR); Multifunctional regulator of fatty acid metabolism.
  
     0.745
HI_1582
Conserved hypothetical protein; Similar to PID:1204257 SP:P52008 GB:U00096 PID:1788183 percent identity: 40.56; identified by sequence similarity; putative; To E.coli YecM.
  
     0.724
HI_1205
Conserved hypothetical protein; Similar to GB:U00096 PID:1788632 GB:U00096 PID:1788632 percent identity: 45.45; identified by sequence similarity; putative.
  
     0.711
HI_1450
Conserved hypothetical protein; Similar to GB:U00096 PID:1787501 percent identity: 48.65; identified by sequence similarity; putative; Belongs to the UPF0263 family.
  
     0.700
metJ
Met repressor (metJ); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
     0.694
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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