Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
trmAtRNA (uracil-5-)-methyltransferase (trmA); Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA). (363 aa)    
Predicted Functional Partners:
rsmJ
Conserved hypothetical protein; Specifically methylates the guanosine in position 1516 of 16S rRNA.
       0.592
HI_1446
Conserved hypothetical protein; Similar to GB:U00096 PID:1787427 percent identity: 41.67; identified by sequence similarity; putative.
  
     0.554
HI_0847
Conserved hypothetical protein; Not known, a mutation in ORF3 causes a slight decrease in transformation efficiency.
       0.480
sixA-A
Conserved hypothetical protein; Similar to GB:U00096 PID:1788681 percent identity: 40.26; identified by sequence similarity; putative; Belongs to the SixA phosphatase family.
  
     0.471
HI_1462.2
Conserved hypothetical protein; Similar to GB:U00096 PID:1788681 percent identity: 40.26; identified by sequence similarity; putative.
  
     0.471
HI_0850
sigma-E factor regulatory protein, putative; Similar to SP:P46187 PID:987645 PID:1045631 PID:1050877 GB:U00096 percent identity: 35.66; identified by sequence similarity; putative.
       0.456
luxS
Conserved hypothetical protein; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD); Belongs to the LuxS family.
  
     0.442
nfuA
orfG protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
    0.411
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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