STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dsbDThiol:disulfide interchange protein (dsbD); Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity); Belongs to the thioredoxin family. DsbD subfamily. (579 aa)    
Predicted Functional Partners:
msrAB
Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
   
 
 0.999
dsbC
Thiol:disulfide interchange protein (dsbC); Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbC is reoxidized by a yet uncharacterized protein. Also acts as a disulfide isomerase (By similarity).
  
 
 0.957
dsbE
Thiol:disulfide interchange protein (dsbE); Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily.
  
 
 0.888
dsbA
Periplasmic oxidoreductase (por); Involved in disulfide-bond formation. Required for HI transformation. Acts by transferring its disulfide bond to other proteins; Belongs to the thioredoxin family. DsbA subfamily.
 
 
 0.857
HI_1115
Thioredoxin, putative; Similar to PID:1213065 SP:P52229 percent identity: 36.36; identified by sequence similarity; putative.
 
 
 0.758
dsbB
Disulfide bond formation protein B (dsbB); Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein; Belongs to the DsbB family.
   
  
 0.735
nrfX
Thiol:disulfide interchange protein (dsbE); Could be involved in disulfide bond formation. Could catalyzes a late, reductive step in the assembly of periplasmic NrfA c- type cytochrome, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase; Belongs to the thioredoxin family. DsbE subfamily.
  
 
 0.725
HI_1453
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 30.84; identified by sequence similarity; putative; Belongs to the thioredoxin family.
  
 
 0.705
HI_1215
Thiol:disulfide interchange protein (dsbA); Similar to PID:840949 SP:P50024 percent identity: 22.28; identified by sequence similarity; putative.
  
 
 0.634
arcA
Aerobic respiration control protein ARCA (arcA); Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions (By similarity).
 
    0.580
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.