Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
emrBMultidrug resistance protein B (emrB); Confers resistance to antibiotics; Belongs to the major facilitator superfamily. EmrB family. (510 aa)    
Predicted Functional Partners:
emrA
Multidrug resistance protein A (emrA); Confers resistance to antibiotics; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.993
folA
Dihydrofolate reductase (folA); Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family.
   
 
 0.550
HI_1462
Conserved hypothetical protein; Similar to GB:U00096 SP:P77211 PID:1778487 PID:1786785 percent identity: 24.32; identified by sequence similarity; putative; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 
 0.549
glpT
Glycerol-3-phosphatase transporter (glpT); Responsible for glycerol-3-phosphate uptake; Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.
   
 
 0.520
mdaB
Modulator of drug activity B (mdaB); NADPH-specific quinone reductase.
      
 0.475
rsmA
Dimethyladenosine transferase (ksgA); Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
      
 0.468
bcr
Bicyclomycin resistance protein (bcr); Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase (By similarity). Belongs to the major facilitator superfamily. Bcr/CmlA family.
  
   
 0.416
pheA
Chorismate mutase / prephenate dehydratase (pheA); Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
   
 
  0.407
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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