STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
emrAMultidrug resistance protein A (emrA); Confers resistance to antibiotics; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (390 aa)    
Predicted Functional Partners:
emrB
Multidrug resistance protein B (emrB); Confers resistance to antibiotics; Belongs to the major facilitator superfamily. EmrB family.
 
 
 0.993
HI_1462
Conserved hypothetical protein; Similar to GB:U00096 SP:P77211 PID:1778487 PID:1786785 percent identity: 24.32; identified by sequence similarity; putative; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 0.949
hsrA
Conserved hypothetical transmembrane protein; Similar to GB:L10328 SP:P31474 PID:290604 GB:U00096 PID:1790195 percent identity: 44.91; identified by sequence similarity; putative.
 
 
 0.902
HI_1340
Conserved hypothetical protein; Similar to PID:882689 GB:U00096 SP:Q46920 PID:1789158 percent identity: 58.08; identified by sequence similarity; putative; Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 0.849
HI_0894
Lipoprotein, putative; Similar to GB:U14993 SP:P43505 PID:438192 PID:550460 percent identity: 30.92; identified by sequence similarity; putative.
 
  
 0.626
HI_0895
Acriflavine resistance protein (acrB); Could be a drug efflux pump; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
  
 0.618
folA
Dihydrofolate reductase (folA); Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity); Belongs to the dihydrofolate reductase family.
     
 0.577
bcr
Bicyclomycin resistance protein (bcr); Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase (By similarity). Belongs to the major facilitator superfamily. Bcr/CmlA family.
   
 
 0.479
hmrM
Conserved hypothetical transmembrane protein; Multidrug efflux pump that functions as a Na(+)/drug antiporter. Confers resistance to norfloxacin, acriflavine, doxorubicin, ethidium bromide, tetraphenylphosphonium chloride, daunomycin, berberine and sodium deoxycholate. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.
      
 0.408
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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