| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HI_0902 | lgt | HI_0902 | HI_0904 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 0.829 |
| HI_0902 | proB | HI_0902 | HI_0900 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.553 |
| HI_0902 | rppH | HI_0902 | HI_0901 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.832 |
| HI_0902 | tadA | HI_0902 | HI_0906 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.771 |
| HI_0902 | thyA | HI_0902 | HI_0905 | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.800 |
| apaH | rnr | HI_0551 | HI_0861 | Diadenosine-tetraphosphatase (apaH); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Virulence-associated protein (vacB); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.475 |
| apaH | rppH | HI_0551 | HI_0901 | Diadenosine-tetraphosphatase (apaH); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.636 |
| dapF | rppH | HI_0750 | HI_0901 | Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration ; Belongs to the diaminopimelate epimerase family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.882 |
| hfq | pcnB | HI_0411 | HI_0063 | Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | poly(A) polymerase (pcnB); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | 0.779 |
| hfq | rnr | HI_0411 | HI_0861 | Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Virulence-associated protein (vacB); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.676 |
| hfq | rppH | HI_0411 | HI_0901 | Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.565 |
| lgt | HI_0902 | HI_0904 | HI_0902 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | 0.829 |
| lgt | proB | HI_0904 | HI_0900 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | 0.577 |
| lgt | rppH | HI_0904 | HI_0901 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.829 |
| lgt | tadA | HI_0904 | HI_0906 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Conserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. | 0.787 |
| lgt | thyA | HI_0904 | HI_0905 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Thymidylate synthetase (thyA); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.829 |
| pcnB | hfq | HI_0063 | HI_0411 | poly(A) polymerase (pcnB); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.779 |
| pcnB | rnr | HI_0063 | HI_0861 | poly(A) polymerase (pcnB); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Virulence-associated protein (vacB); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. | 0.630 |
| pcnB | rppH | HI_0063 | HI_0901 | poly(A) polymerase (pcnB); Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control. Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. | Conserved hypothetical protein; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily. | 0.569 |
| proB | HI_0902 | HI_0900 | HI_0902 | Glutamate 5-kinase (gamma-glutamyl kinase) (proB); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. | Conserved hypothetical protein; Similar to GB:L77117 SP:Q57883 PID:1591145 percent identity: 28.84; identified by sequence similarity; putative. | 0.553 |
