Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
fisHin recombinational enhancer binding protein (fis); Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters; Belongs to the transcriptional regulatory Fis family. (99 aa)    
Predicted Functional Partners:
dusB
Nitrogen fixation protein (nifR3); Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the Dus family. DusB subfamily.
  
  
 0.988
prmA
Ribosomal protein L11 methyltransferase (prmA); Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family.
  
  
 0.668
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.
   
   0.548
sspA
Stringent starvation protein A (sspA); Forms an equimolar complex with the RNA polymerase holoenzyme (RNAP) but not with the core enzyme.
  
   
 0.542
artM
Arginine ABC transporter, permease protein (artM); Part of the ABC transporter complex ArtPIQM involved in arginine transport. Probably responsible for the translocation of the substrate across the membrane (By similarity).
      
 0.513
hfq
Host factor-I protein (hfq); RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family.
 
   
 0.490
priB
Primosomal replication protein N (priB); Binds single-stranded DNA at the primosome assembly site (PAS); Belongs to the PriB family.
   
    0.470
rpoD
RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.
 
   
 0.434
rpsJ
Ribosomal protein S10 (rpS10); Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.
   
    0.433
surA
Stationary phase survival protein SurA, putative; Chaperone involved in the folding of extracytoplasmic proteins.
 
   
 0.419
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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