Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tbpBTransferrin-binding protein 2 precursor (tbp2); Acts as a transferrin receptor and is required for transferrin utilization. (625 aa)    
Predicted Functional Partners:
tbpA
Transferrin-binding protein 1 precursor (tbp1); Acts as a transferrin receptor and is required for transferrin utilization; Belongs to the TonB-dependent receptor family.
  
  
 0.863
HI_0996
Predicted coding region HI0996; Hypothetical protein; identified by GeneMark; putative.
       0.546
HI_0661
Hemoglobin-binding protein; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.
   
  
 0.537
exbB
Biopolymer transport protein (exbB); Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. Protects ExbD from proteolytic degradation and functionally stabilizes TonB (By similarity).
      
 0.521
hxuA
Heme-hemopexin utilization protein A (hxuA); Binds heme/hemopexin complexes.
      
 0.425
HI_0635
Hemoglobin-binding protein; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.
   
  
 0.420
HI_1565
Hemoglobin-binding protein; Similar to PID:1000292 PID:984513 percent identity: 54.76; identified by sequence similarity; putative.
   
  
 0.420
HI_0712
Hemoglobin-binding protein; Acts as a receptor for hemoglobin or the hemoglobin/haptoglobin complex of the human host and is required for heme uptake.
      
 0.414
dnaA
Chromosomal replication initiator protein (dnaA); Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
       0.408
recF
DNA/ATP binding protein (recF); The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).
       0.401
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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