| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HI_0840 | ccmD | HI_0840 | HI_1092 | Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family. | Heme exporter protein D (ccmD); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.671 |
| HI_0840 | fadR | HI_0840 | HI_0426 | Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family. | Fatty acid metabolism regulator protein (fadR); Multifunctional regulator of fatty acid metabolism. | 0.745 |
| HI_0840 | rraB | HI_0840 | HI_0700 | Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family. | Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. | 0.746 |
| HI_0840 | seqA | HI_0840 | HI_0192 | Conserved hypothetical protein; Similar to SP:P33921 PID:405915 GB:U00096 PID:1788514 percent identity: 45.71; identified by sequence similarity; putative; Belongs to the UPF0352 family. | seqA protein (seqA); Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. | 0.773 |
| ccmA | ccmB | HI_1089 | HI_1090 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | 0.999 |
| ccmA | ccmC | HI_1089 | HI_1091 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | 0.999 |
| ccmA | ccmD | HI_1089 | HI_1092 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Heme exporter protein D (ccmD); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.968 |
| ccmA | ccmE | HI_1089 | HI_1093 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Cytochrome C-type biogenesis protein (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. | 0.989 |
| ccmA | ccmF | HI_1089 | HI_1094 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Cytochrome C-type biogenesis protein (ccmF); Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase; Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. | 0.928 |
| ccmA | dsbE | HI_1089 | HI_1095 | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | Thiol:disulfide interchange protein (dsbE); Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. | 0.808 |
| ccmB | ccmA | HI_1090 | HI_1089 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | 0.999 |
| ccmB | ccmC | HI_1090 | HI_1091 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | 0.999 |
| ccmB | ccmD | HI_1090 | HI_1092 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Heme exporter protein D (ccmD); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.981 |
| ccmB | ccmE | HI_1090 | HI_1093 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Cytochrome C-type biogenesis protein (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. | 0.992 |
| ccmB | ccmF | HI_1090 | HI_1094 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Cytochrome C-type biogenesis protein (ccmF); Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase; Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. | 0.908 |
| ccmB | dsbE | HI_1090 | HI_1095 | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | Thiol:disulfide interchange protein (dsbE); Involved in disulfide bond formation. Catalyzes a late, reductive step in the assembly of periplasmic c-type cytochromes, probably the reduction of disulfide bonds of the apocytochrome c to allow covalent linkage with the heme. Possible subunit of a heme lyase (By similarity); Belongs to the thioredoxin family. DsbE subfamily. | 0.853 |
| ccmC | ccmA | HI_1091 | HI_1089 | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | Heme exporter ATP-binding protein A (ccmA); Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. | 0.999 |
| ccmC | ccmB | HI_1091 | HI_1090 | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | Heme exporter protein B (ccmB); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. | 0.999 |
| ccmC | ccmD | HI_1091 | HI_1092 | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | Heme exporter protein D (ccmD); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. | 0.990 |
| ccmC | ccmE | HI_1091 | HI_1093 | Heme exporter protein C (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. | Cytochrome C-type biogenesis protein (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. | 0.998 |
