| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HI_1159 | PGdx | HI_1159 | HI_0572 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | 0.576 |
| HI_1159 | dnaJ | HI_1159 | HI_1238 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | 0.665 |
| HI_1159 | gor | HI_1159 | HI_0161 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Glutathione reductase (gor); Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.964 |
| HI_1159 | groL | HI_1159 | HI_0543 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.870 |
| HI_1159 | grpE | HI_1159 | HI_0071 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.878 |
| HI_1159 | hslU | HI_1159 | HI_0497 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (hslU); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.901 |
| HI_1159 | hslV | HI_1159 | HI_0496 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (hslV); Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.900 |
| HI_1159 | htpG | HI_1159 | HI_0104 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Heat shock protein (htpG); Molecular chaperone. Has ATPase activity. | 0.706 |
| HI_1159 | rseA | HI_1159 | HI_0629 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | sigma-E factor negative regulatory protein (mclA); An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytopl [...] | 0.642 |
| HI_1159 | trxB | HI_1159 | HI_1158 | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | Thioredoxin reductase (trxB); Similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096 percent identity: 75.95; identified by sequence similarity; putative. | 0.906 |
| PGdx | HI_1159 | HI_0572 | HI_1159 | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | 0.576 |
| PGdx | dnaJ | HI_0572 | HI_1238 | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | 0.425 |
| PGdx | gor | HI_0572 | HI_0161 | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | Glutathione reductase (gor); Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.972 |
| PGdx | trxB | HI_0572 | HI_1158 | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | Thioredoxin reductase (trxB); Similar to GB:J03762 SP:P09625 PID:148073 PID:347239 GB:U00096 percent identity: 75.95; identified by sequence similarity; putative. | 0.686 |
| dnaJ | HI_1159 | HI_1238 | HI_1159 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Conserved hypothetical protein; Similar to GB:U00096 SP:P77395 PID:1773174 PID:1786700 percent identity: 50.89; identified by sequence similarity; putative. | 0.665 |
| dnaJ | PGdx | HI_1238 | HI_0572 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Membrane protein; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; In the C-terminal section; belongs to the glutaredoxin family. | 0.425 |
| dnaJ | groL | HI_1238 | HI_0543 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Heat shock protein (groEL); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.982 |
| dnaJ | grpE | HI_1238 | HI_0071 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Heat shock protein (grpE); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of AT [...] | 0.994 |
| dnaJ | hslU | HI_1238 | HI_0497 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Heat shock protein (hslU); ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.962 |
| dnaJ | hslV | HI_1238 | HI_0496 | Heat shock protein (dnaJ); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ [...] | Heat shock protein (hslV); Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.946 |
