Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
hemHFerrochelatase (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (323 aa)    
Predicted Functional Partners:
HI_0854
Conserved hypothetical protein; Involved in heme iron utilization. Catalyzes the degradation of heme to biliverdin, with the release of iron and carbon monoxide.
     
  0.920
HI_1161
Conserved hypothetical protein; Similar to GB:M24143 SP:P15050 PID:450383 PID:522184 GB:U00096 percent identity: 49.26; identified by sequence similarity; putative; Belongs to the thioesterase PaaI family.
       0.832
cyaY
cyaY protein (cyaY); Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
    
 0.820
lon
ATP-dependent proteinase (lon); ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.
     
  0.712
clpP
ATP-dependent Clp protease, proteolytic subunit (clpP); Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
    
 0.579
HI_1208
Conserved hypothetical protein; Similar to GB:L42023 PID:1007092 PID:1221333 PID:1205451 PID:1574138 percent identity: 100.00; identified by sequence similarity; putative; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
  
  
 0.539
msrAB
Peptide methionine sulfoxide reductase (msrA); Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
      
 0.509
ccmE
Cytochrome C-type biogenesis protein (ccmE); Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
      
 0.507
frdB
Fumarate reductase, iron-sulfur protein (frdB); Similar to GB:U14003 SP:P00364 GB:J01611 PID:145264 PID:536997 percent identity: 75.51; identified by sequence similarity; putative.
    
 
 0.483
grcA
Conserved hypothetical protein; Acts as a radical domain for damaged PFL and possibly other radical proteins.
      
 0.468
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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