Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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gmhAPhosphoheptose isomerase (gmhA); Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (194 aa)    
Predicted Functional Partners:
hldE
ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
  
 0.998
gmhB
Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate, phospho-serine and fructose-1,6-biphosphate in vitro. Belongs to the GmhB family.
 
 0.993
hldD
ADP-L-glycero-D-mannoheptose-6-epimerase (rfaD); Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose.
 
  
 0.844
rfaF
ADP-heptose--LPS heptosyltransferase II (rfaF); Similar to SP:P37692 PID:466758 GB:U00096 PID:1790050 percent identity: 63.58; identified by sequence similarity; putative.
 
   
 0.817
kdsA
2-dehydro-3-deoxyphosphooctonate aldolase (kdsA); Similar to SP:P17579 GB:X05552 PID:940498 PID:968934 GB:U00096 percent identity: 81.63; identified by sequence similarity; putative; Belongs to the KdsA family.
   
 
 0.682
lpxA
UDP-N-acetylglucosamine acetyltransferase (lpxA); Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.
   
 
 0.672
galE
UDP-glucose 4-epimerase (galE); Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae.
  
  
 0.659
galU
Glucosephosphate uridylyltransferase (galU); May play a role in stationary phase survival; Belongs to the UDPGP type 2 family.
     
 0.658
lpxH
Conserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the LpxH family.
      
 0.646
wecA
Undecaprenyl-phosphate alpha-N-acetylglucosaminyltransferase (rfe), putative; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). Belongs to the glycosyltransferase 4 family. WecA subfamily.
     
 0.635
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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