STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cysBCys regulon transcriptional activator (cysB); This protein is a positive regulator of gene expression for the cysteine regulon. The inducer for CysB is N-acetylserine (By similarity). (323 aa)    
Predicted Functional Partners:
rluB
Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; Belongs to the pseudouridine synthase RsuA family.
       0.767
gcvA
Glycine cleavage system transcriptional activator (gcvA); Not known, the gcv operon regulated by the E.coli homolog does not exist in H.influenzae, so it probably acts as a transcriptional regulator on some other operon; Belongs to the LysR transcriptional regulatory family.
 
     0.689
cysE
Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative.
      
 0.618
HI_1198
Conserved hypothetical protein; Similar to SP:P45847 PID:602960 GB:U00096 PID:1787521 percent identity: 71.30; identified by sequence similarity; putative; Belongs to the SUA5 family.
       0.615
rseB
sigma-E factor regulatory protein (rseB); Negatively modulates the activity of sigma-E (RpoE) by stabilizing RseA under non-stress conditions. Although not essential for association of sigma-E with Rsea it increases their affinity 2- to 3-fold. When bound to RseA it prevents proteolysis by DegS, which is probably relieved by lipopolysaccharide binding (LPS) (By similarity). Belongs to the RseB family.
  
     0.519
rpoC
DNA-directed RNA polymerase, beta' chain (rpoC); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
 
 0.504
fnr
Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration.
  
   0.469
rpoA
DNA-directed RNA polymerase, alpha chain (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.467
cysK
Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family.
      
 0.466
rlmM
Conserved hypothetical protein; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.
 
     0.463
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.