node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysE | cysK | HI_0606 | HI_1103 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.995 |
cysE | glyA | HI_0606 | HI_0889 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.654 |
cysE | ilvA | HI_0606 | HI_0738.1 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.617 |
cysE | metB | HI_0606 | HI_0086 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Cystathionine gamma-synthase (metB); Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). | 0.575 |
cysE | metXA | HI_0606 | HI_1263 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Homoserine acetyltransferase (met2); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. | 0.636 |
cysE | thrA | HI_0606 | HI_0089 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.804 |
cysE | thrB | HI_0606 | HI_0088 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.605 |
cysE | trpC | HI_0606 | HI_1389.1 | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.804 |
cysK | cysE | HI_1103 | HI_0606 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | 0.995 |
cysK | glyA | HI_1103 | HI_0889 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.712 |
cysK | ilvA | HI_1103 | HI_0738.1 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.705 |
cysK | metB | HI_1103 | HI_0086 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Cystathionine gamma-synthase (metB); Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity). | 0.908 |
cysK | metE | HI_1103 | HI_1702 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase (metE); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.692 |
cysK | metXA | HI_1103 | HI_1263 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Homoserine acetyltransferase (met2); Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. Utilizes a ping-pong kinetic mechanism in which the acetyl group of acetyl-CoA is initially transferred to the enzyme to form an acetyl- enzyme intermediate before subsequent transfer to homoserine to form the final product, O-acetylhomoserine. | 0.704 |
cysK | thrA | HI_1103 | HI_0089 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.808 |
cysK | thrB | HI_1103 | HI_0088 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Homoserine kinase (thrB); Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.641 |
cysK | trpC | HI_1103 | HI_1389.1 | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC); Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity). | 0.826 |
glyA | cysE | HI_0889 | HI_0606 | Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase (cysE); Similar to SP:P05796 GB:M15745 GB:M34333 PID:145676 PID:145694 percent identity: 73.05; identified by sequence similarity; putative. | 0.654 |
glyA | cysK | HI_0889 | HI_1103 | Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Cysteine synthetase (cysK); Similar to GB:M21451 SP:P11096 GB:X12615 PID:145686 PID:41201 percent identity: 70.65; identified by sequence similarity; putative; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.712 |
glyA | ilvA | HI_0889 | HI_0738.1 | Serine hydroxymethyltransferase (serine methylase) (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine deaminase (ilvA); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). | 0.691 |