STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gloBHydroxyacylglutathione hydrolase, putative; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl- glutathione to form glutathione and D-lactic acid (238 aa)    
Predicted Functional Partners:
gloA
Lactoylglutathione lyase (gloa); Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione
 
 
 0.999
dld
D-lactate dehydrogenase (dld); Catalyzes the oxidation of D-lactate to pyruvate
     
 0.998
gloC
Conserved hypothetical protein; Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S- lactoylglutathione to (R)-lactate and glutathione. Plays a role in methylglyoxal (MG) detoxification
  
 
0.987
ddh
D-lactate dehydrogenase, fermentative (ldha); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
  
  0.983
grxD
Conserved hypothetical protein; Monothiol glutaredoxin involved in the biogenesis of iron- sulfur clusters
  
  
 0.864
mgsA
Methylglyoxal synthase (mgsa); Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate
      
 0.745
HI_1273
Uncharacterized protein HI_1273; Similar to PID:1816658 percent identity: 37.25; identified by sequence similarity; putative
  
 
 0.703
HI_1272
Abc transporter, atp-binding protein; Belongs to the ABC transporter superfamily
   
   0.700
kefBC
Glutathione-regulated potassium efflux system protein (kefc); Transport system that facilitate potassium-efflux, possibly by potassium-proton antiport
  
  
 0.672
HI_1163
Uncharacterized protein HI_1163; Similar to GB:U00096 SP:P77748 PID:1742760 PID:1787977 percent identity: 60.82; identified by sequence similarity; putative
    
 0.649
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: low (6%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.