Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HI_1369Conserved hypothetical protein; Similar to SP:P31827 GB:X71917 PID:311346 GB:U00096 PID:1787771 percent identity: 25.46; identified by sequence similarity; putative; To E.coli YddB. (839 aa)    
Predicted Functional Partners:
tonB
tonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Required for heme utilization and virulence; Belongs to the TonB family.
 
 0.951
pqqL
Zinc protease, putative; Similar to SP:P31828 GB:X71917 PID:535004 GB:U00096 PID:1742451 percent identity: 28.76; identified by sequence similarity; putative.
 
  
 0.850
HI_1217
Transferrin-binding protein, putative; Probable receptor, TonB-dependent.
  
 
  0.803
HI_1624
Predicted coding region HI1624; Hypothetical protein; identified by GeneMark; putative.
 
     0.776
HI_1405
Predicted coding region HI1405; Hypothetical protein; identified by GeneMark; putative.
  
     0.770
oapA
Opacity associated protein (oapA); Cell envelope protein involved in phase variation, confers opaque colony phenotype; Belongs to the OapA family.
  
     0.767
HI_1409
Predicted coding region HI1409; Hypothetical protein; identified by GeneMark; putative.
  
     0.754
HI_1697
Lipopolysaccharide biosynthesis protein, putative; Similar to GB:U05670 percent identity: 28.57; identified by sequence similarity; putative; Belongs to the glycosyltransferase 25 family.
  
     0.728
HI_0162
Lipoprotein, putative; Similar to GB:U00096 PID:1773118 PID:1786637 percent identity: 25.82; identified by sequence similarity; putative.
  
     0.708
HI_1326
Predicted coding region HI1326; Hypothetical protein; identified by GeneMark; putative.
  
     0.698
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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