| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| crp | fnr | HI_0957 | HI_1425 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | 0.656 |
| crp | pta | HI_0957 | HI_1203 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | Phosphate acetyltransferase (pta); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. | 0.665 |
| crp | rpoA | HI_0957 | HI_0802 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | DNA-directed RNA polymerase, alpha chain (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.928 |
| crp | rpoB | HI_0957 | HI_0515 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | DNA-directed RNA polymerase, beta chain (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.882 |
| crp | rpoC | HI_0957 | HI_0514 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | DNA-directed RNA polymerase, beta' chain (rpoC); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.883 |
| crp | rpoD | HI_0957 | HI_0533 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.936 |
| crp | rpoH | HI_0957 | HI_0269 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | RNA polymerase sigma-32 factor (rpoH); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. | 0.620 |
| crp | rpoZ | HI_0957 | HI_1742 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | DNA-directed RNA polymerase, omega chain (rpoZ); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.880 |
| crp | thrA | HI_0957 | HI_0089 | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.525 |
| fnr | crp | HI_1425 | HI_0957 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | 0.656 |
| fnr | pta | HI_1425 | HI_1203 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | Phosphate acetyltransferase (pta); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. | 0.608 |
| fnr | rpoA | HI_1425 | HI_0802 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | DNA-directed RNA polymerase, alpha chain (rpoA); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.652 |
| fnr | rpoB | HI_1425 | HI_0515 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | DNA-directed RNA polymerase, beta chain (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.657 |
| fnr | rpoC | HI_1425 | HI_0514 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | DNA-directed RNA polymerase, beta' chain (rpoC); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.633 |
| fnr | rpoD | HI_1425 | HI_0533 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | RNA polymerase sigma-70 factor (rpoD); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.522 |
| fnr | rpoH | HI_1425 | HI_0269 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | RNA polymerase sigma-32 factor (rpoH); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. | 0.549 |
| fnr | rpoZ | HI_1425 | HI_1742 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | DNA-directed RNA polymerase, omega chain (rpoZ); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.632 |
| fnr | thrA | HI_1425 | HI_0089 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.525 |
| fnr | uspE | HI_1425 | HI_1426 | Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration. | Conserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. | 0.835 |
| pta | crp | HI_1203 | HI_0957 | Phosphate acetyltransferase (pta); Involved in acetate metabolism; In the N-terminal section; belongs to the CobB/CobQ family. | Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...] | 0.665 |
