Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
uspEConserved hypothetical protein; Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family. (340 aa)    
Predicted Functional Partners:
fnr
Fumarate (and nitrate) reduction regulatory protein (fnr); It is involved in the activation of genes necessary for anaerobic respiration.
 
  
 0.835
uspA
Universal stress protein A (uspA); Required for resistance to DNA-damaging agents. Belongs to the universal stress protein A family.
   
  
 0.749
HI_1205
Conserved hypothetical protein; Similar to GB:U00096 PID:1788632 GB:U00096 PID:1788632 percent identity: 45.45; identified by sequence similarity; putative.
  
     0.718
nlpI
Conserved hypothetical protein; May be involved in cell division.
  
     0.655
sdhE
Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
  
     0.655
HI_0847
Conserved hypothetical protein; Not known, a mutation in ORF3 causes a slight decrease in transformation efficiency.
  
     0.620
proQ
Predicted coding region HI1670; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family.
  
   
 0.608
rraB
Conserved hypothetical protein; Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome.
  
     0.581
HI_0839
Conserved hypothetical protein; Similar to SP:P33920 PID:405914 GB:U00096 PID:1788513 percent identity: 52.38; identified by sequence similarity; putative.
  
     0.570
metJ
Met repressor (metJ); This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis; Belongs to the MetJ family.
  
     0.564
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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