Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
prfAPeptide chain release factor 1 (prfA); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (361 aa)    
Predicted Functional Partners:
prmC
hemK protein (hemK); Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.
 
 
 0.994
rpmA
Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family.
 
 0.914
rplT
Ribosomal protein L20 (rpL20); Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
  
 0.904
rplO
Ribosomal protein L15 (rpL15); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
 
 0.899
rplM
Ribosomal protein L13 (rpL13); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
 
 0.887
rpsG
Ribosomal protein S7 (rpS7); One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family.
  
 0.882
rplP
Ribosomal protein L16 (rpL16); Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family.
  
 0.882
rplQ
Ribosomal protein L17 (rplQ); Similar to GB:J01685 SP:P02416 GB:X00766 PID:147716 PID:42800 percent identity: 89.76; identified by sequence similarity; putative.
 
 0.882
rplC
Ribosomal protein L3 (rpL3); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
 
 0.872
rpsP
Ribosomal protein S16 (rpS16); Similar to SP:P02372 PID:43143 GB:U00096 PID:1788961 percent identity: 70.73; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bS16 family.
 
 0.864
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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