node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
alaA | alr | HI_0286 | HI_1575 | Aminotransferase; Involved in the biosynthesis of alanine. | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.666 |
alaA | ddl | HI_0286 | HI_1140 | Aminotransferase; Involved in the biosynthesis of alanine. | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | 0.612 |
alaA | murF | HI_0286 | HI_1134 | Aminotransferase; Involved in the biosynthesis of alanine. | UDP-MurNAc-pentapeptide synthetase (murF); Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.600 |
alaA | tsaE | HI_0286 | HI_0065 | Aminotransferase; Involved in the biosynthesis of alanine. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro. | 0.564 |
alr | alaA | HI_1575 | HI_0286 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Aminotransferase; Involved in the biosynthesis of alanine. | 0.666 |
alr | ddl | HI_1575 | HI_1140 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | 0.874 |
alr | dnaB | HI_1575 | HI_1574 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Replicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. | 0.831 |
alr | murB | HI_1575 | HI_0268 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation. | 0.733 |
alr | murC | HI_1575 | HI_1139 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramate--alanine ligase (murC); Cell wall formation; Belongs to the MurCDEF family. | 0.694 |
alr | murD | HI_1575 | HI_1136 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.727 |
alr | murE | HI_1575 | HI_1133 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-N-acetylmuramyl-tripeptide synthetase (murE); Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.773 |
alr | murF | HI_1575 | HI_1134 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | UDP-MurNAc-pentapeptide synthetase (murF); Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. | 0.985 |
alr | murI | HI_1575 | HI_1739.2 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Glutamate racemase (murI); Provides the (R)-glutamate required for cell wall biosynthesis. | 0.678 |
alr | tsaE | HI_1575 | HI_0065 | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD (By similarity). Displays ATPase activity in vitro. | 0.680 |
ddl | alaA | HI_1140 | HI_0286 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | Aminotransferase; Involved in the biosynthesis of alanine. | 0.612 |
ddl | alr | HI_1140 | HI_1575 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | Alanine racemase, biosynthetic (alr); Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. | 0.874 |
ddl | murB | HI_1140 | HI_0268 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | UDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation. | 0.888 |
ddl | murC | HI_1140 | HI_1139 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | UDP-N-acetylmuramate--alanine ligase (murC); Cell wall formation; Belongs to the MurCDEF family. | 0.997 |
ddl | murD | HI_1140 | HI_1136 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.973 |
ddl | murE | HI_1140 | HI_1133 | D-alanine--D-alanine ligase (ddlB); Cell wall formation. | UDP-N-acetylmuramyl-tripeptide synthetase (murE); Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.941 |