Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
HI_1605Conserved hypothetical protein; Similar to SP:P39202 PID:1203798 GB:U00096 PID:1789435 percent identity: 40.72; identified by sequence similarity; putative. (203 aa)    
Predicted Functional Partners:
cca
tRNA nucleotidyltransferase (cca); Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases.
  
  
 0.850
guaA
GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP.
    
  0.786
lolB
hemM protein (hemM); Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
 
     0.753
HI_0221.1
Predicted coding region HI0221.1; Brute Force ORF; identified by GeneMark; putative; Belongs to the IMPDH/GMPR family.
    
  0.712
tamB
Conserved hypothetical protein; Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM (By similarity).
  
     0.689
guaB
Inosine-5'-monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
  0.677
HI_0431
Conserved hypothetical protein; Similar to SP:P32680 PID:396338 GB:U00096 PID:1790432 percent identity: 54.59; identified by sequence similarity; putative; To E.coli YjaG.
  
     0.673
HI_1603
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 28.84; identified by sequence similarity; putative; Belongs to the UPF0111 family.
 
     0.663
HI_1604
Phosphate permease, putative; Potential transporter for phosphate; Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.
       0.654
HI_0603
uroporphyrin-III C-methyltransferase (hemX); Similar to GB:M87049 SP:P09127 GB:X12614 GB:X13406 PID:148202 percent identity: 40.45; identified by sequence similarity; putative; To E.coli HemX N-terminal region.
  
     0.606
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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