Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (164 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase (purL); Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 
 0.999
purD
Phosphoribosylamine--glycine ligase (purD); Similar to SP:P15640 GB:J05126 GB:X51950 PID:147421 PID:396344 percent identity: 75.18; identified by sequence similarity; putative.
 0.999
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family.
 0.999
purB
Adenylosuccinate lyase (purB); Similar to GB:M74924 SP:P25739 PID:145203 PID:42585 GB:U00096 percent identity: 76.97; identified by sequence similarity; putative.
  
 0.996
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC); Similar to PID:1144522 SP:Q59566 PID:1550658 percent identity: 46.67; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family.
  
 
 0.996
purM
Phosphoribosylaminoimidazole synthetase (purM); Similar to GB:M13747 SP:P08178 PID:147425 GB:U00096 PID:1788845 percent identity: 76.30; identified by sequence similarity; putative.
 
 
 0.992
purF
Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.988
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (purH); Similar to SP:P15639 GB:J05126 GB:X51950 PID:147420 PID:396345 percent identity: 77.19; identified by sequence similarity; putative.
 
  
 0.977
purN
Phosphoribosylglycinamide formyltransferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.976
purA
Adenylosuccinate synthetase (purA); Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.973
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.