Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
Score
dapD2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (dapD); Similar to GB:X63201 SP:P41396 PID:38947 percent identity: 96.70; identified by sequence similarity; putative; Belongs to the transferase hexapeptide repeat family. (303 aa)    
Predicted Functional Partners:
dapB
Dihydrodipicolinate reductase (dapB); Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
 
 
 0.984
dapE
Succinyl-diaminopimelate desuccinylase (dapE); Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. It can only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L- SDAP) and is inactive toward D,L-, L,D-, and D,D-SDAP.
 
   
 0.790
dapF
Diaminopimelate epimerase (dapF); Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration ; Belongs to the diaminopimelate epimerase family.
 
  
 0.698
dapA
Dihydrodipicolinate synthetase (dapA); Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.674
thrA
Aspartokinase I / homoserine dehydrogenase I (thrA); Similar to SP:P00561 GB:M10644 GB:V00360 GB:V00361 PID:147979 percent identity: 62.21; identified by sequence similarity; putative; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
  
 0.672
guaA
GMP synthase (guaA); Catalyzes the synthesis of GMP from XMP.
   
  
 0.621
alaA
Aminotransferase; Involved in the biosynthesis of alanine.
    
 0.521
purR
Purine nucleotide synthesis repressor (purR); Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression.
   
   0.520
HI_1632
Predicted coding region HI1632; Hypothetical protein; identified by GeneMark; putative; Belongs to the aspartokinase family.
 
  
 0.506
abgA
Hydrolase; Catalyzes the cleavage of p-aminobenzoyl-glutamate (PABA-GLU) to form p-aminobenzoate (PABA) and glutamate.
 
  
 0.497
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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