STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ppcPhosphoenolpyruvate carboxylase (ppc); Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (879 aa)    
Predicted Functional Partners:
pckA
Phosphoenolpyruvate carboxykinase (pckA); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.
     
 0.963
mdh
Malate dehydrogenase (mdh); Catalyzes the reversible oxidation of malate to oxaloacetate.
     
 0.953
pykA
Pyruvate kinase, type II (pykA); Similar to GB:M63703 SP:P21599 GB:M87660 PID:147459 PID:146878 percent identity: 77.24; identified by sequence similarity; putative; Belongs to the pyruvate kinase family.
     
 0.952
pgk
Phosphoglycerate kinase (pgk); Similar to SP:P11665 PID:41422 PID:882455 GB:U00096 PID:1789294 percent identity: 81.14; identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family.
  
 
 0.947
eno
Enolase (eno); Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
   
 
 0.946
gpmA
Phosphoglycerate mutase (gpmA); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily.
     
 0.925
fdxH
Formate dehydrogenase, beta subunit (fdxH); Allows to use formate as major electron donor during aerobic respiration. The beta chain is an electron transfer unit containing 4 cysteine clusters involved in the formation of iron-sulfur centers. Electrons are transferred from the gamma chain to the molybdenum cofactor of the alpha subunit (By similarity).
     
 0.924
fdxI
Formate dehydrogenase, gamma subunit (fdxI); Allows to use formate as major electron donor during anaerobic respiration. Subunit gamma is probably the cytochrome b556(FDO) component of the formate dehydrogenase (By similarity).
     
 0.924
purU
Formyltetrahydrofolate deformylase (purU); Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
     
  0.920
sucD
succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
    
 0.635
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.