Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dldD-lactate dehydrogenase (dld); Catalyzes the oxidation of D-lactate to pyruvate. Belongs to the quinone-dependent D-lactate dehydrogenase family. (564 aa)    
Predicted Functional Partners:
lldD
L-lactate dehydrogenase (lctD); Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain; Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
 
 0.985
pykA
Pyruvate kinase, type II (pykA); Similar to GB:M63703 SP:P21599 GB:M87660 PID:147459 PID:146878 percent identity: 77.24; identified by sequence similarity; putative; Belongs to the pyruvate kinase family.
    
 0.969
maeB
Malate oxidoreductase, putative; Similar to GB:U00096 PID:1788806 PID:1799885 PID:1799887 percent identity: 68.69; identified by sequence similarity; putative; In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.
  
 
 0.940
pflB
Formate acetyltransferase (pfl); Similar to GB:X08035 SP:P09373 PID:42370 GB:U00096 PID:1651427 percent identity: 86.09; identified by sequence similarity; putative.
     
 0.931
gloC
Conserved hypothetical protein; Type II glyoxalase, isozyme of GloB, that hydrolyzes (R)-S- lactoylglutathione to (R)-lactate and glutathione. Plays a role in methylglyoxal (MG) detoxification.
  
  
  0.930
ddh
D-lactate dehydrogenase, fermentative (ldhA); Similar to PID:1049265 SP:P52643 GB:U00096 PID:1742253 PID:1742259 percent identity: 70.86; identified by sequence similarity; putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.
   
 0.928
alaA
Aminotransferase; Involved in the biosynthesis of alanine.
   
 
 0.922
leuA
2-isopropylmalate synthase (leuA); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
     
  0.920
leuC
3-isopropylmalate dehydratase, alpha subunit (leuC); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
     
  0.920
leuD
3-isopropylmalate dehydratase small subunit (leuD); Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
     
  0.920
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.