Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_1657Conserved hypothetical protein; Similar to SP:P45466 PID:606089 GB:U00096 PID:1789539 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the SIS family. DiaA subfamily. (194 aa)    
Predicted Functional Partners:
gmhB
Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position in vitro. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7- bisphosphate, phospho-serine and fructose-1,6-biphosphate in vitro. Belongs to the GmhB family.
 
 
 0.910
hldE
ADP-heptose synthase (rfaE); Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
 
  
 0.863
lpoA
Antigen; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a).
  
    0.832
HI_1656
Conserved hypothetical protein; Similar to SP:P45465 PID:606088 GB:U00096 PID:1789538 percent identity: 48.67; identified by sequence similarity; putative; Belongs to the UPF0102 family.
  
    0.832
HI_1658
Hemolysin, putative; Similar to SP:P45467 PID:606090 GB:U00096 PID:1789540 percent identity: 51.10; identified by sequence similarity; putative.
  
    0.750
rfaF
ADP-heptose--LPS heptosyltransferase II (rfaF); Similar to SP:P37692 PID:466758 GB:U00096 PID:1790050 percent identity: 63.58; identified by sequence similarity; putative.
 
   
 0.699
rsmI
Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
       0.635
hisB
Imidazoleglycerol-phosphate dehydratase / histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 64.97; identified by sequence similarity; putative; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.
  
 
 0.633
dnaA
Chromosomal replication initiator protein (dnaA); Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity).
    
 
 0.565
recQ
ATP-dependent DNA helicase (recQ); DNA helicase; Belongs to the helicase family. RecQ subfamily.
     
  0.540
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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