| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HI_0304 | nrdA | HI_0304 | HI_1659 | Conserved hypothetical protein; Similar to PID:882477 SP:P52049 GB:U00096 PID:1789317 percent identity: 44.57; identified by sequence similarity; putative; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.961 |
| HI_1309 | nrdA | HI_1309 | HI_1659 | Conserved hypothetical protein; Similar to SP:P37910 GB:U00096 PID:1788568 percent identity: 54.41; identified by sequence similarity; putative. | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.861 |
| HI_1309 | nrdB | HI_1309 | HI_1660 | Conserved hypothetical protein; Similar to SP:P37910 GB:U00096 PID:1788568 percent identity: 54.41; identified by sequence similarity; putative. | Ribonucleoside diphosphate reductase, beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.885 |
| adk | gmk | HI_0349 | HI_1743 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | 0.835 |
| adk | ndk | HI_0349 | HI_0876 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.959 |
| adk | nrdA | HI_0349 | HI_1659 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.938 |
| adk | nrdB | HI_0349 | HI_1660 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Ribonucleoside diphosphate reductase, beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.936 |
| adk | polA | HI_0349 | HI_0856 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.541 |
| adk | tmk | HI_0349 | HI_0456 | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.656 |
| gmk | adk | HI_1743 | HI_0349 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | 0.835 |
| gmk | ndk | HI_1743 | HI_0876 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.972 |
| gmk | nrdA | HI_1743 | HI_1659 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.920 |
| gmk | nrdB | HI_1743 | HI_1660 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | Ribonucleoside diphosphate reductase, beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.921 |
| gmk | polA | HI_1743 | HI_0856 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.595 |
| gmk | spoT | HI_1743 | HI_1741 | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | Guanosine-3',5'-bis(diphosphate) 3'- pyrophosphohydrolase (spoT); In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the degradation of ppGpp into GDP. It may also be capable of catalyzing the synthesis of ppGpp (By similarity); Belongs to the RelA/SpoT family. | 0.951 |
| grxA | nrdA | HI_1532 | HI_1659 | Glutaredoxin (grx); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.877 |
| ndk | adk | HI_0876 | HI_0349 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Adenylate kinase (adk); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity). It may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae. Belongs to the adenylate kinase family. | 0.959 |
| ndk | gmk | HI_0876 | HI_1743 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Guanylate kinase (gmk); Essential for recycling GMP and indirectly, cGMP. | 0.972 |
| ndk | nrdA | HI_0876 | HI_1659 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside-diphosphate reductase, alpha chain (nrdA); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.961 |
| ndk | nrdB | HI_0876 | HI_1660 | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | Ribonucleoside diphosphate reductase, beta chain (nrdB); Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.960 |
