Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_1672Conserved hypothetical protein; Similar to GB:U00096 PID:1736475 PID:1736481 PID:1788138 percent identity: 42.94; identified by sequence similarity; putative. (881 aa)    
Predicted Functional Partners:
HI_1671
Conserved hypothetical protein; Similar to GB:U00096 PID:1736474 PID:1736480 PID:1788137 percent identity: 43.04; identified by sequence similarity; putative.
 
 0.990
mlaF
ABC transporter, ATP-binding protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Responsible for energy coupling to the transport system.
    
 0.653
proQ
Predicted coding region HI1670; RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities; Belongs to the ProQ family.
       0.589
mlaE
Conserved hypothetical protein; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for the translocation of the substrate across the membrane.
    
 0.584
mlaB
Anti-sigma factor B antagonist, putative; Part of the ABC transporter complex MlaFEDB, which is involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. MlaB plays critical roles in both the assembly and activity of the complex. May act by modulating MlaF structure and stability.
     
  0.522
mlaC
Conserved hypothetical protein; Involved in a phospholipid transport pathway that maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. May transfer phospholipid across the periplasmic space and deliver it to the MlaFEDB complex at the inner membrane. Belongs to the MlaC/ttg2D family.
     
  0.522
HI_0341
Conserved hypothetical protein; Similar to SP:P38521 PID:882488 GB:U00096 PID:1789329 percent identity: 55.65; identified by sequence similarity; putative; To E.coli YggL.
  
     0.505
HI_1582
Conserved hypothetical protein; Similar to PID:1204257 SP:P52008 GB:U00096 PID:1788183 percent identity: 40.56; identified by sequence similarity; putative; To E.coli YecM.
  
     0.499
prc
Tail specific protease (prc); Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 (PBP3). May be involved in protection of the bacterium from thermal and osmotic stresses (By similarity).
       0.494
HI_1665
Predicted coding region HI1665; Hypothetical protein; identified by GeneMark; putative.
 
     0.468
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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