Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
HI_1724Conserved hypothetical protein; Similar to SP:P45567 GB:U00096 PID:1786310 percent identity: 38.98; identified by sequence similarity; putative; Belongs to the UPF0231 family. (132 aa)    
Predicted Functional Partners:
erpA
Conserved hypothetical protein; Required for insertion of 4Fe-4S clusters for at least IspG.
       0.824
mrcB
Penicillin-binding protein 1B (ponB); Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits) (By similarity).
       0.814
HI_0845
Conserved hypothetical protein; Similar to GB:L19201 SP:P32126 PID:304964 GB:U00096 PID:1790289 percent identity: 65.91; identified by sequence similarity; putative; To E.coli YihD.
  
     0.723
HI_0866
Predicted coding region HI0866; Hypothetical protein; identified by GeneMark; putative.
  
     0.698
matP
Conserved hypothetical protein; Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain.
  
     0.672
HI_0341
Conserved hypothetical protein; Similar to SP:P38521 PID:882488 GB:U00096 PID:1789329 percent identity: 55.65; identified by sequence similarity; putative; To E.coli YggL.
  
     0.666
trpR
Trp operon repressor (trpR); This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription (By similarity).
  
     0.659
HI_1582
Conserved hypothetical protein; Similar to PID:1204257 SP:P52008 GB:U00096 PID:1788183 percent identity: 40.56; identified by sequence similarity; putative; To E.coli YecM.
  
     0.654
HI_1543
Conserved hypothetical protein; Similar to GB:U00096 SP:P75915 PID:1787272 percent identity: 39.78; identified by sequence similarity; putative; Belongs to the TorD/DmsD family.
  
     0.652
crp
Catabolite gene activator (crp); A global transcription regulator required for bacterial competence. Complexes with cyclic AMP (cAMP) which allosterically activates DNA binding (to consensus sequence 5'-AAATGTGATCTAGATCACATTT- 3') to regulate transcription at 54 promoters. There are 2 consensus subclasses; CRP-N (above) and CRP-S (T6 changed to C and A17 changed to G) which obligatorily also requires Sxy for expression. CRP-S sites bind DNA but do not activate transcription in the absence of Sxy. Probably induces a severe bend in DNA. Probably acts as a negative regulator of its own sy [...]
    
   0.643
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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