STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
prfCPeptide chain release factor 3 (prfC); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity); Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (527 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1 (prfA); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
   
 
 0.882
rpmA
Ribosomal protein L27 (rpL27); Similar to GB:D13267 SP:P02427 PID:216637 PID:606123 GB:U00096 percent identity: 87.06; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL27 family.
   
 
 0.870
rplC
Ribosomal protein L3 (rpL3); One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.
    
  0.847
rplL
Ribosomal protein L7/L12 (rpL7/L12); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.
   
 
 0.845
rplK
Ribosomal protein L11 (rpL11); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
    
  0.834
rplT
Ribosomal protein L20 (rpL20); Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity).
  
 
 0.833
rplS
Ribosomal protein L19 (rpL19); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
   
   0.830
rpmG
Ribosomal protein L33 (rpL33); Similar to GB:J01677 SP:P02436 PID:147709 PID:290486 GB:U00096 percent identity: 81.48; identified by sequence similarity; putative; Belongs to the bacterial ribosomal protein bL33 family.
   
   0.814
rplI
Ribosomal protein L9 (rpL9); Binds to the 23S rRNA.
   
   0.809
rplQ
Ribosomal protein L17 (rplQ); Similar to GB:J01685 SP:P02416 GB:X00766 PID:147716 PID:42800 percent identity: 89.76; identified by sequence similarity; putative.
   
   0.804
Your Current Organism:
Haemophilus influenzae
NCBI taxonomy Id: 71421
Other names: H. influenzae Rd KW20, Haemophilus influenzae KW20, Haemophilus influenzae Rd, Haemophilus influenzae Rd KW20
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.