STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EcREcdysone receptor; Receptor for ecdysone. Binds to ecdysone response elements (ECRES); Belongs to the nuclear hormone receptor family. NR1 subfamily. (776 aa)    
Predicted Functional Partners:
USP
AAEL000395-PA.
   
0.999
AAEL002382
AAEL002382-PA.
    
 0.949
e75B
Ecdysone-induced protein 75B.
   
0.834
InR
Insulin-like receptor alpha chain; This receptor probably binds an insulin related protein and has a tyrosine-protein kinase activity.
    
 0.724
AAEL007402
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).
    
 0.685
J9HEY8_AEDAE
AAEL017391-PA.
    
 0.677
AAEL010715
AAEL010715-PA.
 
      0.665
Cdk8
Cyclin-dependent kinase 8; Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C- terminal domain) of the l [...]
    
 0.616
AAEL013609
AAEL013609-PA.
      
 0.593
AAEL005380
AAEL005380-PA.
    
 
 0.581
Your Current Organism:
Aedes aegypti
NCBI taxonomy Id: 7159
Other names: A. aegypti, Stegomyia aegypti, yellow fever mosquito
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