STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DEFADefensin-A; Antibacterial peptide mostly active against Gram-positive bacteria. Has activity against the bacteria Gram-negative E.cloacae beta12. Belongs to the invertebrate defensin family. Type 1 subfamily. (98 aa)    
Predicted Functional Partners:
REL1
Dorsal isoform 1-A.
     
 0.960
REL1B
AAEL006930-PA.
     
 0.908
DEFC
Defensin-C; Antibacterial peptide mostly active against Gram-positive bacteria; Belongs to the invertebrate defensin family. Type 1 subfamily.
     
0.900
IMD
AAEL010083-PA.
      
 0.748
CECA
Cecropin-A; Antibacterial activity against Gram-negative bacteria E.coli D22 and D31, E.carotovora, K.pneumoniae, P.aeruginosa, S.typhimurium, E.cloacae B12 and X.campestris and Gram-positive bacteria A.viridans, M.luteus, B.megaterium and S.pyogenes. Possesses antifungal activity against F.oxysporum, F.culmorum and N.crassa, C.albicans, C.neoformans and S.cerevisiae. No activity against Gram-negative S.marcescens Db11, Gram-positive B.cereus, B.subtilis, B.thuringiensis, S.aureus and L.monocytogenes, the fungi A.fumigatus and B.bassiana and C.glabrata.
   
  
 0.684
REL2
AAEL007624-PA.
      
 0.559
ATT
AAEL003389-PA.
   
  
 0.532
AAEL006874
Prophenoloxidase.
      
 0.499
AAEL006877
Prophenoloxidase.
      
 0.499
PPO2
Prophenoloxidase.
      
 0.497
Your Current Organism:
Aedes aegypti
NCBI taxonomy Id: 7159
Other names: A. aegypti, Stegomyia aegypti, yellow fever mosquito
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.