A7USP1_ANOGA protein (Anopheles gambiae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

A7USP1_ANOGA

Protein osiris 22. (366 aa)

Predicted Functional Partners:

A0NCY1_ANOGA

0.611

F5HK15_ANOGA

0.521

Q7QB98_ANOGA

0.420

Your Current Organism:

Anopheles gambiae

NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto

Network Stats

number of nodes:

11

number of edges:

10

average node degree:

1.82

avg. local clustering coefficient:

0.909

expected number of edges:

10

PPI enrichment p-value:

0.563

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006355

Regulation of transcription, DNA-templated

9 of 5033

0.96

0.92

8.90e-05

GO:0050794

Regulation of cellular process

10 of 10335

0.69

0.6

0.00016

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003700

DNA-binding transcription factor activity

11 of 3204

1.24

1.95

5.88e-11

GO:0008270

Zinc ion binding

6 of 1176

1.41

1.66

1.62e-05

GO:0043565

Sequence-specific DNA binding

7 of 2081

1.23

1.4

1.52e-05

GO:0003677

DNA binding

11 of 5479

1.01

1.26

7.10e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17441

Nuclear Receptor transcription pathway, and Transcription factor AIG1-like

7 of 41

2.94

8.01

6.84e-16

CL:17442

Transcription factor AIG1-like, and Nuclear Receptor transcription pathway

6 of 32

2.98

6.96

9.55e-14

CL:17444

Transcription factor AIG1-like, and Nuclear Receptor transcription pathway

5 of 26

2.99

5.6

4.10e-11

CL:12469

Mixed, incl. F-box protein At5g50450/At1g67340-like, and Elongin complex

4 of 16

3.1

4.44

7.48e-09

CL:17446

Transcription factor AIG1-like, and Nuclear Receptor transcription pathway

4 of 20

3.01

4.28

1.37e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-383280

Nuclear Receptor transcription pathway

6 of 17

3.25

8.16

9.69e-16

MAP-212436

Generic Transcription Pathway

6 of 1253

1.39

1.59

2.38e-05

MAP-8951664

Neddylation

4 of 510

1.6

1.45

0.00049

MAP-73857

RNA Polymerase II Transcription

6 of 1899

1.21

1.18

0.00018

MAP-74160

Gene expression (Transcription)

6 of 2439

1.1

0.99

0.00049

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

10 of 8152

0.79

0.73

6.80e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04749

PLAC8 family

6 of 34

2.95

6.87

1.28e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006461

PLAC8 motif-containing protein

6 of 34

2.95

6.64

3.72e-13

IPR044759

RF2-like transcription factor, bZIP domain

4 of 25

2.91

3.84

8.56e-08

IPR046347

Basic-leucine zipper domain superfamily

4 of 147

2.14

2.18

4.94e-05

IPR004827

Basic-leucine zipper domain

4 of 148

2.14

2.18

4.94e-05

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00338

Basic region leucin zipper

4 of 155

2.12

2.43

1.30e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

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node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0NCY1_ANOGA	A7USP1_ANOGA	A0NCY1	A7USP1	AGAP003419-PA.	Protein osiris 22.	0.611
A7USP1_ANOGA	A0NCY1_ANOGA	A7USP1	A0NCY1	Protein osiris 22.	AGAP003419-PA.	0.611
A7USP1_ANOGA	F5HK15_ANOGA	A7USP1	F5HK15	Protein osiris 22.	AGAP013345-PA.	0.521
A7USP1_ANOGA	Q7QB98_ANOGA	A7USP1	Q7QB98	Protein osiris 22.	Protein osiris 1.	0.420
F5HK15_ANOGA	A7USP1_ANOGA	F5HK15	A7USP1	AGAP013345-PA.	Protein osiris 22.	0.521
Q7QB98_ANOGA	A7USP1_ANOGA	Q7QB98	A7USP1	Protein osiris 1.	Protein osiris 22.	0.420