STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
pkProtein prickle; Acts in a planar cell polarity (PCP) complex; polarization along the apical/basal axis of epithelial cells. PCP signaling in the wing disk requires the receptor fz and the cytoplasmic proteins dsh and pk. These act in a feedback loop leading to activation of the jnk cascade and subsequent polarized arrangement of hairs and bristles. Dgo and pk compete with one another for dsh binding, thereby modulating fz dsh activity and ensuring tight control over fz PCP signaling. Vang, stan and pk function together to regulate the establishment of tissue polarity in the adult eye [...] (923 aa)    
Predicted Functional Partners:
F5HLP0_ANOGA
AGAP004448-PB.
    
 0.992
Q7Q072_ANOGA
Vang-like protein.
    
 0.988
A0NEC2_ANOGA
AGAP005398-PA.
     
 
0.900
A0NGN3_ANOGA
AGAP012051-PA.
    
 0.736
GPRSTN
AGAP004850-PA; Belongs to the G-protein coupled receptor 2 family.
   
 0.717
GPRFZ3
AGAP000168-PA; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.672
Q7Q0Z1_ANOGA
AGAP010058-PA.
      
 0.648
Q7QE88_ANOGA
AGAP000773-PA.
      
 0.648
Q7PSQ3_ANOGA
E3 ubiquitin-protein ligase.
     
 0.627
nkd
Protein naked cuticle homolog; Cell autonomous antagonist of the canonical Wnt signaling pathway. May activate a second Wnt signaling pathway that controls planar cell polarity. Required for neuroblast specification (By similarity); Belongs to the NKD family.
      
 0.595
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto
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