STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F5HLW2_ANOGAUbiquitin carboxyl-terminal hydrolase. (724 aa)    
Predicted Functional Partners:
Q7PNF5_ANOGA
AGAP008494-PA.
    
 0.840
Q7PUE3_ANOGA
AGAP001882-PA.
    
 0.794
Q7PWQ2_ANOGA
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
    
 0.784
F7IUE6_ANOGA
Polyubiquitin-C.
    
 0.726
Q7PR02_ANOGA
AGAP002599-PA.
    
 0.726
Q5TTC4_ANOGA
AGAP004228-PA.
    
 0.710
Q7Q3K7_ANOGA
60S ribosomal protein L40.
   
 0.706
Q7PTA8_ANOGA
26S proteasome regulatory subunit T6; Belongs to the AAA ATPase family.
    
 0.594
Q7PYP0_ANOGA
Zinc finger, FYVE domain containing 1.
    
 0.574
Q7QH42_ANOGA
Vacuolar protein sorting 24.
    
 
 0.549
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.