HOT_ANOGA protein (Anopheles gambiae) - STRING interaction network

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HOT_ANOGA

Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily. (464 aa)

Predicted Functional Partners:

Q7Q8X4_ANOGA

0.996

Q7QA76_ANOGA

0.924

Q7QDR1_ANOGA

0.921

Q7PY23_ANOGA

0.904

Q7PTS8_ANOGA

0.897

Q7PTS9_ANOGA

0.897

Q7Q8B0_ANOGA

0.884

Q7PXM0_ANOGA

0.872

Q7Q597_ANOGA

0.872

Q7Q1U8_ANOGA

0.834

Your Current Organism:

Anopheles gambiae

NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HOT_ANOGA	Q7PTS8_ANOGA	Q7Q547	Q7PTS8	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Iron-regulated short-chain dehydrogenase/reductase.	0.897
HOT_ANOGA	Q7PTS9_ANOGA	Q7Q547	Q7PTS9	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Hydroxysteroid dehydrogenase-like protein 2.	0.897
HOT_ANOGA	Q7PXM0_ANOGA	Q7Q547	Q7PXM0	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Propionyl-CoA synthetase.	0.872
HOT_ANOGA	Q7PY23_ANOGA	Q7Q547	Q7PY23	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	NADH dehydrogenase (ubiquinone) Fe-S protein 8.	0.904
HOT_ANOGA	Q7Q1U8_ANOGA	Q7Q547	Q7Q1U8	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Glyceraldehyde-3-phosphate dehydrogenase.	0.834
HOT_ANOGA	Q7Q597_ANOGA	Q7Q547	Q7Q597	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Acetyl-coenzyme A synthetase.	0.872
HOT_ANOGA	Q7Q8B0_ANOGA	Q7Q547	Q7Q8B0	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	AGAP008717-PA.	0.884
HOT_ANOGA	Q7Q8X4_ANOGA	Q7Q547	Q7Q8X4	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	AGAP010499-PA.	0.996
HOT_ANOGA	Q7QA76_ANOGA	Q7Q547	Q7QA76	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	Acetyl-CoA hydrolase/transferase (Precursor).	0.924
HOT_ANOGA	Q7QDR1_ANOGA	Q7Q547	Q7QDR1	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.921
Q7PTS8_ANOGA	HOT_ANOGA	Q7PTS8	Q7Q547	Iron-regulated short-chain dehydrogenase/reductase.	Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial; Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2- KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity); Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.	0.897
Q7PTS8_ANOGA	Q7PTS9_ANOGA	Q7PTS8	Q7PTS9	Iron-regulated short-chain dehydrogenase/reductase.	Hydroxysteroid dehydrogenase-like protein 2.	0.677
Q7PTS8_ANOGA	Q7PXM0_ANOGA	Q7PTS8	Q7PXM0	Iron-regulated short-chain dehydrogenase/reductase.	Propionyl-CoA synthetase.	0.883
Q7PTS8_ANOGA	Q7PY23_ANOGA	Q7PTS8	Q7PY23	Iron-regulated short-chain dehydrogenase/reductase.	NADH dehydrogenase (ubiquinone) Fe-S protein 8.	0.466
Q7PTS8_ANOGA	Q7Q1U8_ANOGA	Q7PTS8	Q7Q1U8	Iron-regulated short-chain dehydrogenase/reductase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.468
Q7PTS8_ANOGA	Q7Q597_ANOGA	Q7PTS8	Q7Q597	Iron-regulated short-chain dehydrogenase/reductase.	Acetyl-coenzyme A synthetase.	0.883
Q7PTS8_ANOGA	Q7Q8B0_ANOGA	Q7PTS8	Q7Q8B0	Iron-regulated short-chain dehydrogenase/reductase.	AGAP008717-PA.	0.601
Q7PTS8_ANOGA	Q7Q8X4_ANOGA	Q7PTS8	Q7Q8X4	Iron-regulated short-chain dehydrogenase/reductase.	AGAP010499-PA.	0.445
Q7PTS8_ANOGA	Q7QA76_ANOGA	Q7PTS8	Q7QA76	Iron-regulated short-chain dehydrogenase/reductase.	Acetyl-CoA hydrolase/transferase (Precursor).	0.663
Q7PTS8_ANOGA	Q7QDR1_ANOGA	Q7PTS8	Q7QDR1	Iron-regulated short-chain dehydrogenase/reductase.	2-hydroxyacyl-CoA lyase 1; Belongs to the TPP enzyme family.	0.687

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