STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q7QDI2_ANOGAAGAP003437-PA. (167 aa)    
Predicted Functional Partners:
Q7PT27_ANOGA
Vacuolar protein sorting-associated protein 35; Plays a role in vesicular protein sorting.
   
 0.995
Q7Q5Y3_ANOGA
Vacuolar protein sorting 26.
    
 0.988
Q7QFK9_ANOGA
AGAP000545-PA.
    
 0.957
Q7QBW4_ANOGA
Vacuolar protein sorting-associated protein 29; Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.
   
 0.953
A0NF88_ANOGA
Predicted G-protein coupled receptor GPCR.
    
 0.907
Q7PVK3_ANOGA
Sorting nexin-2.
   
0.788
Q7PP58_ANOGA
AGAP006652-PA; Belongs to the peptidase C19 family.
    
 0.742
Q7PWQ2_ANOGA
Hepatocyte growth factor-regulated tyrosine kinase substrate; Essential role in endosome membrane invagination and formation of multivesicular bodies, MVBs. Required during gastrulation and appears to regulate early embryonic signaling pathways. Inhibits tyrosine kinase receptor signaling by promoting degradation of the tyrosine-phosphorylated, active receptor, potentially by sorting activated receptors into MVBs. The MVBs are then trafficked to the lysosome where their contents are degraded.
    
 
 0.692
A0NGX8_ANOGA
Sorting nexin family member 27 isoform 1.
    
 
 0.679
Q7QA12_ANOGA
Sorting nexin; Involved in several stages of intracellular trafficking.
    
 
 0.676
Your Current Organism:
Anopheles gambiae
NCBI taxonomy Id: 7165
Other names: A. gambiae, African malaria mosquito, Anopheles gambiae S, Anopheles gambiae sensu stricto
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