Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ghrA2-ketoacid reductase; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. (312 aa)    
Predicted Functional Partners:
ECL_00267
Isocitrate lyase.
   
 
 0.929
ghrB
D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrB subfamily.
 
  
 
0.913
gph
Phosphoglycolate phosphatase; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family.
    
 0.912
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 
 0.908
ECL_00266
Malate synthase; Belongs to the malate synthase family.
     
 0.906
ECL_01448
Keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase.
    
  0.898
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 0.898
garR
Tartronate semialdehyde reductase; Catalyzes the reduction of tatronate semialdehyde to D- glycerate; Belongs to the HIBADH-related family. 2-hydroxy-3- oxopropionate reductase subfamily.
    
  0.897
ECL_04119
Glycerate 2-kinase; Belongs to the glycerate kinase type-1 family.
    
  0.894
ECL_02333
Glyoxalase I; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.
     
  0.893
Your Current Organism:
Enterobacter cloacae
NCBI taxonomy Id: 716541
Other names: E. cloacae subsp. cloacae ATCC 13047, Enterobacter cloacae subsp. cloacae ATCC 13047, Enterobacter cloacae subsp. cloacae str. ATCC 13047, Enterobacter cloacae subsp. cloacae strain ATCC 13047
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