Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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norVAnaerobic nitric oxide reductase flavorubredoxin; Anaerobic nitric oxide reductase; uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center; electrons enter from the NorW at rubredoxin and are transferred sequentially to the FMN center and the di-iron center. Also able to function as an aerobic oxygen reductase; In the N-terminal section; belongs to the zinc metallo- hydrolase group 3 family. (480 aa)    
Predicted Functional Partners:
norW
Nitric oxide reductase; One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
 0.999
ECL_01616
Nitrite reductase (NAD(P)H) large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 0.982
ECL_04742
Nitrite reductase (NAD(P)H), large subunit; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
  
 0.975
hcp-2
Hydroxylamine reductase; Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.
 
   
 0.857
ECL_01839
Pyruvate flavodoxin/ferredoxin oxidoreductase domain-containing protein.
 
 
 0.844
ECL_04602
Glutamate synthase large subunit.
  
 
 0.835
norR
Anaerobic nitric oxide reductase transcription regulator; Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54.
 
   
 0.817
ECL_04260
Putative ferredoxin reductase subunit.
    
 0.815
ECL_00717
PAS sensor protein.
    
 0.809
ECL_01392
Ferritin-like protein 2; Iron-storage protein.
 
  
 0.772
Your Current Organism:
Enterobacter cloacae
NCBI taxonomy Id: 716541
Other names: E. cloacae subsp. cloacae ATCC 13047, Enterobacter cloacae subsp. cloacae ATCC 13047, Enterobacter cloacae subsp. cloacae str. ATCC 13047, Enterobacter cloacae subsp. cloacae strain ATCC 13047
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