STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thyXPutative alternative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (546 aa)    
Predicted Functional Partners:
wcw_1035
Conserved hypothetical protein.
  
     0.704
pbp2
Cell division protein FtsI/penicillin-binding protein 2.
  
     0.680
wcw_0843
Conserved hypothetical protein; FOG: WD40 repeat.
  
     0.668
wcw_0569
Conserved hypothetical protein; Predicted Rossmann fold nucleotide-binding protein.
  
     0.654
wcw_0801
Uncharacterized protein conserved in bacteria.
  
     0.642
tdk3
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
    
 0.632
dut
Deoxyuridine 5`-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.631
wcw_1167
Conserved hypothetical protein.
  
     0.627
wcw_1976
Uncharacterized protein conserved in bacteria.
  
     0.569
yaeL
Metalloprotease; Predicted membrane-associated Zn-dependent proteases 1.
 
     0.566
Your Current Organism:
Waddlia chondrophila
NCBI taxonomy Id: 716544
Other names: W. chondrophila WSU 86-1044, Waddlia chondrophila WSU 86-1044
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.