node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDZ87144.1 | SDZ87181.1 | SAMN02982996_00516 | SAMN02982996_00517 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | Hypothetical protein. | 0.777 |
SDZ87144.1 | SDZ87208.1 | SAMN02982996_00516 | SAMN02982996_00518 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.414 |
SDZ87144.1 | SDZ87234.1 | SAMN02982996_00516 | SAMN02982996_00519 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.414 |
SDZ87144.1 | SEA99314.1 | SAMN02982996_00516 | SAMN02982996_03186 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | Hypothetical protein. | 0.462 |
SDZ87144.1 | cysG | SAMN02982996_00516 | SAMN02982996_01415 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.790 |
SDZ87144.1 | hemC | SAMN02982996_00516 | SAMN02982996_02934 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.462 |
SDZ87144.1 | hemE | SAMN02982996_00516 | SAMN02982996_03295 | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.479 |
SDZ87181.1 | SDZ87144.1 | SAMN02982996_00517 | SAMN02982996_00516 | Hypothetical protein. | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | 0.777 |
SDZ87181.1 | SDZ87208.1 | SAMN02982996_00517 | SAMN02982996_00518 | Hypothetical protein. | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.414 |
SDZ87181.1 | SDZ87234.1 | SAMN02982996_00517 | SAMN02982996_00519 | Hypothetical protein. | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.414 |
SDZ87208.1 | SDZ87144.1 | SAMN02982996_00518 | SAMN02982996_00516 | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | 0.414 |
SDZ87208.1 | SDZ87181.1 | SAMN02982996_00518 | SAMN02982996_00517 | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Hypothetical protein. | 0.414 |
SDZ87208.1 | SDZ87234.1 | SAMN02982996_00518 | SAMN02982996_00519 | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.815 |
SDZ87234.1 | SDZ87144.1 | SAMN02982996_00519 | SAMN02982996_00516 | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | 0.414 |
SDZ87234.1 | SDZ87181.1 | SAMN02982996_00519 | SAMN02982996_00517 | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Hypothetical protein. | 0.414 |
SDZ87234.1 | SDZ87208.1 | SAMN02982996_00519 | SAMN02982996_00518 | Fe-S cluster biosynthesis and repair protein YggX; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | A/G-specific DNA-adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.815 |
SEA99314.1 | SDZ87144.1 | SAMN02982996_03186 | SAMN02982996_00516 | Hypothetical protein. | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | 0.462 |
cysG | SDZ87144.1 | SAMN02982996_01415 | SAMN02982996_00516 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | DNA-binding winged helix-turn-helix (wHTH) domain-containing protein. | 0.790 |
cysG | hemC | SAMN02982996_01415 | SAMN02982996_02934 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
cysG | hemE | SAMN02982996_01415 | SAMN02982996_03295 | uroporphyrin-III C-methyltransferase / precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.871 |