A0A4Y7SHD9 protein (Coprinellus micaceus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

A0A4Y7SHD9

Uncharacterized protein. (590 aa)

Predicted Functional Partners:

A0A4Y7SQE8

0.898

A0A4Y7SXW3

0.675

A0A4Y7TB23

0.622

A0A4Y7SYW0

0.567

A0A4Y7SPZ8

0.510

A0A4Y7TI98

0.510

A0A4Y7SRD7

0.509

A0A4Y7T1E5

0.509

A0A4Y7SXE6

0.483

A0A4Y7TIW5

0.465

Your Current Organism:

Coprinellus micaceus

NCBI taxonomy Id: 71717
Other names: C. micaceus, Coprinus micaceus

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A4Y7SHD9	A0A4Y7SPZ8	Uncharacterized protein.	Kinase-like protein.	0.510
A0A4Y7SHD9	A0A4Y7SQE8	Uncharacterized protein.	Uncharacterized protein.	0.898
A0A4Y7SHD9	A0A4Y7SRD7	Uncharacterized protein.	Ankyrin.	0.509
A0A4Y7SHD9	A0A4Y7SXE6	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.483
A0A4Y7SHD9	A0A4Y7SXW3	Uncharacterized protein.	Kinase-like protein.	0.675
A0A4Y7SHD9	A0A4Y7SYW0	Uncharacterized protein.	Uncharacterized protein.	0.567
A0A4Y7SHD9	A0A4Y7T1E5	Uncharacterized protein.	Ankyrin.	0.509
A0A4Y7SHD9	A0A4Y7TB23	Uncharacterized protein.	EGF-like domain-containing protein.	0.622
A0A4Y7SHD9	A0A4Y7TI98	Uncharacterized protein.	ANK_REP_REGION domain-containing protein.	0.510
A0A4Y7SHD9	A0A4Y7TIW5	Uncharacterized protein.	GRIP domain-containing protein.	0.465
A0A4Y7SPZ8	A0A4Y7SHD9	Kinase-like protein.	Uncharacterized protein.	0.510
A0A4Y7SPZ8	A0A4Y7SQE8	Kinase-like protein.	Uncharacterized protein.	0.996
A0A4Y7SPZ8	A0A4Y7SRD7	Kinase-like protein.	Ankyrin.	0.737
A0A4Y7SPZ8	A0A4Y7SXW3	Kinase-like protein.	Kinase-like protein.	0.845
A0A4Y7SPZ8	A0A4Y7T1E5	Kinase-like protein.	Ankyrin.	0.737
A0A4Y7SPZ8	A0A4Y7TB23	Kinase-like protein.	EGF-like domain-containing protein.	0.469
A0A4Y7SPZ8	A0A4Y7TI98	Kinase-like protein.	ANK_REP_REGION domain-containing protein.	0.744
A0A4Y7SPZ8	A0A4Y7TIW5	Kinase-like protein.	GRIP domain-containing protein.	0.851
A0A4Y7SQE8	A0A4Y7SHD9	Uncharacterized protein.	Uncharacterized protein.	0.898
A0A4Y7SQE8	A0A4Y7SPZ8	Uncharacterized protein.	Kinase-like protein.	0.996

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

6.25e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009132

Nucleoside diphosphate metabolic process

7 of 58

2.45

6.02

4.55e-13

GO:0072528

Pyrimidine-containing compound biosynthetic process

5 of 28

2.62

4.81

5.53e-10

GO:0009142

Nucleoside triphosphate biosynthetic process

5 of 29

2.6

4.78

6.02e-10

GO:0009141

Nucleoside triphosphate metabolic process

6 of 73

2.28

4.67

1.67e-10

GO:0090407

Organophosphate biosynthetic process

9 of 281

1.87

4.45

4.55e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

6 of 25

2.74

6.13

1.82e-12

GO:0019205

Nucleobase-containing compound kinase activity

6 of 29

2.68

6.04

2.01e-12

GO:0004550

Nucleoside diphosphate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0004017

Adenylate kinase activity

3 of 4

3.24

3.23

1.41e-06

GO:0016772

Transferase activity, transferring phosphorus-containing groups

7 of 765

1.32

1.68

2.39e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36277867

(2022) Cold-induced denaturation of muscle proteins in hairtail (Trichiurus lepturus) during storage: Physicochemical and label-free based proteomics analyses.

3 of 52

2.12

1.26

0.0040

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5678

Purine metabolism

9 of 40

2.72

9.69

3.16e-20

CL:5732

Mixed, incl. CTP metabolic process, and Adenylate kinase activity

7 of 13

3.09

9.1

9.18e-18

CL:5673

Mixed, incl. Purine metabolism, and Metabolism of nucleotides

10 of 157

2.17

7.13

1.42e-18

CL:5748

Adenylate kinase activity, and ATP cone domain

4 of 5

3.27

4.99

8.16e-10

CL:5734

Nucleoside diphosphate kinase, and Purine ribonucleoside bisphosphate metabolic process

2 of 5

2.97

1.63

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pvm00230

Purine metabolism

9 of 76

2.44

8.5

2.35e-19

pvm00730

Thiamine metabolism

5 of 10

3.06

6.48

9.96e-13

pvm00240

Pyrimidine metabolism

5 of 36

2.51

5.02

1.24e-10

pvm00983

Drug metabolism - other enzymes

4 of 49

2.28

3.42

1.40e-07

pvm01100

Metabolic pathways

10 of 991

1.37

2.44

3.87e-12

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-499943

Interconversion of nucleotide di- and triphosphates

5 of 21

2.74

4.93

4.73e-10

MAP-15869

Metabolism of nucleotides

6 of 104

2.12

4.02

1.80e-09

MAP-1430728

Metabolism

7 of 2301

0.85

0.61

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

7 of 411

1.59

2.59

2.75e-08

KW-0547

Nucleotide-binding

6 of 685

1.31

1.48

2.31e-05

KW-0067

ATP-binding

5 of 552

1.32

1.33

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13207

AAA domain

3 of 5

3.14

2.93

4.83e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR034907

Nucleoside diphosphate kinase-like domain

3 of 3

3.36

2.93

5.10e-06

IPR001564

Nucleoside diphosphate kinase

3 of 3

3.36

2.93

5.10e-06

IPR036850

Nucleoside diphosphate kinase-like domain superfamily

3 of 5

3.14

2.92

5.10e-06

IPR033690

Adenylate kinase, conserved site

3 of 5

3.14

2.92

5.10e-06

IPR000850

Adenylate kinase/UMP-CMP kinase

3 of 6

3.06

2.91

5.10e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00562

These are enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates. These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.

3 of 3

3.36

3.43

6.44e-07

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