A0A4Y7TK43 protein (Coprinellus micaceus) - STRING interaction network

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Predicted Interactions

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A0A4Y7TK43

Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (218 aa)

Predicted Functional Partners:

COQ7

0.976

A0A4Y7SY69

0.973

A0A4Y7SD70

0.879

A0A4Y7TEQ4

0.855

A0A4Y7TG60

0.840

COQ4

0.819

A0A4Y7TQY0

0.787

A0A4Y7TRH7

0.787

A0A4Y7T6B0

0.769

A0A4Y7TA14

0.713

Your Current Organism:

Coprinellus micaceus

NCBI taxonomy Id: 71717
Other names: C. micaceus, Coprinus micaceus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A4Y7SD70	A0A4Y7TG60	A0A4Y7SD70	A0A4Y7TG60	ABC1 domain-containing protein.	COQ6 monooxygenase.	0.805
A0A4Y7SD70	A0A4Y7TK43	A0A4Y7SD70	A0A4Y7TK43	ABC1 domain-containing protein.	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.	0.879
A0A4Y7SD70	A0A4Y7TQY0	A0A4Y7SD70	A0A4Y7TQY0	ABC1 domain-containing protein.	Ubiquinone biosynthesis O-methyltransferase.	0.893
A0A4Y7SD70	A0A4Y7TRH7	A0A4Y7SD70	A0A4Y7TRH7	ABC1 domain-containing protein.	Uncharacterized protein.	0.893
A0A4Y7SD70	COQ4	A0A4Y7SD70	A0A4Y7TK84	ABC1 domain-containing protein.	Ubiquinone biosynthesis protein COQ4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family.	0.619
A0A4Y7SD70	COQ7	A0A4Y7SD70	A0A4Y7TPK7	ABC1 domain-containing protein.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	0.802
A0A4Y7SY69	A0A4Y7T6B0	A0A4Y7SY69	A0A4Y7T6B0	RING/U-box.	Ribosomal protein L2.	0.959
A0A4Y7SY69	A0A4Y7TA14	A0A4Y7SY69	A0A4Y7TA14	RING/U-box.	Uncharacterized protein.	0.971
A0A4Y7SY69	A0A4Y7TEQ4	A0A4Y7SY69	A0A4Y7TEQ4	RING/U-box.	Ribosomal protein L2.	0.979
A0A4Y7SY69	A0A4Y7TK43	A0A4Y7SY69	A0A4Y7TK43	RING/U-box.	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.	0.973
A0A4Y7T6B0	A0A4Y7SY69	A0A4Y7T6B0	A0A4Y7SY69	Ribosomal protein L2.	RING/U-box.	0.959
A0A4Y7T6B0	A0A4Y7TA14	A0A4Y7T6B0	A0A4Y7TA14	Ribosomal protein L2.	Uncharacterized protein.	0.879
A0A4Y7T6B0	A0A4Y7TK43	A0A4Y7T6B0	A0A4Y7TK43	Ribosomal protein L2.	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.	0.769
A0A4Y7TA14	A0A4Y7SY69	A0A4Y7TA14	A0A4Y7SY69	Uncharacterized protein.	RING/U-box.	0.971
A0A4Y7TA14	A0A4Y7T6B0	A0A4Y7TA14	A0A4Y7T6B0	Uncharacterized protein.	Ribosomal protein L2.	0.879
A0A4Y7TA14	A0A4Y7TEQ4	A0A4Y7TA14	A0A4Y7TEQ4	Uncharacterized protein.	Ribosomal protein L2.	0.914
A0A4Y7TA14	A0A4Y7TK43	A0A4Y7TA14	A0A4Y7TK43	Uncharacterized protein.	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.	0.713
A0A4Y7TEQ4	A0A4Y7SY69	A0A4Y7TEQ4	A0A4Y7SY69	Ribosomal protein L2.	RING/U-box.	0.979
A0A4Y7TEQ4	A0A4Y7TA14	A0A4Y7TEQ4	A0A4Y7TA14	Ribosomal protein L2.	Uncharacterized protein.	0.914
A0A4Y7TEQ4	A0A4Y7TK43	A0A4Y7TEQ4	A0A4Y7TK43	Ribosomal protein L2.	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.	0.855

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

17

PPI enrichment p-value:

5.71e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

10 of 153

1.87

5.08

6.75e-16

GO:0043248

Proteasome assembly

5 of 17

2.53

4.59

1.13e-09

GO:0006511

Ubiquitin-dependent protein catabolic process

11 of 230

1.74

4.47

3.75e-16

GO:0045862

Positive regulation of proteolysis

5 of 25

2.36

4.13

5.36e-09

GO:0070682

Proteasome regulatory particle assembly

4 of 9

2.71

3.92

4.34e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

4 of 6

2.88

3.78

1.07e-07

GO:0016887

ATP hydrolysis activity

4 of 190

1.38

0.83

0.0134

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 37

2.53

10.95

6.26e-25

GO:0005838

Proteasome regulatory particle

9 of 21

2.69

9.89

7.78e-21

GO:0008540

Proteasome regulatory particle, base subcomplex

5 of 9

2.8

5.52

3.76e-11

GO:0008541

Proteasome regulatory particle, lid subcomplex

4 of 11

2.62

3.9

4.09e-08

GO:0034515

Proteasome storage granule

4 of 14

2.51

3.71

7.63e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2026

Proteasome complex

11 of 34

2.57

11.12

6.42e-25

CL:2028

Proteasome complex

10 of 26

2.64

10.74

3.36e-23

CL:2030

Proteasome accessory complex

8 of 14

2.81

9.25

8.31e-19

CL:2032

Proteasome regulatory particle, base subcomplex, and Proteasome regulatory particle, lid subcomplex

6 of 8

2.93

7.07

4.93e-14

CL:2058

Proteasome subunit

2 of 11

2.32

1.09

0.0096

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 42

2.48

10.75

3.86e-25

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 41

2.49

10.56

1.85e-24

MAP-1236975

Antigen processing-Cross presentation

11 of 42

2.48

10.51

1.85e-24

MAP-5689880

Ub-specific processing proteases

11 of 81

2.19

8.19

5.49e-22

MAP-5688426

Deubiquitination

11 of 117

2.03

6.87

1.86e-20

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 191

1.82

5.23

2.66e-18

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 108

2.07

7.01

3.47e-20

GOCC:0005838

Proteasome regulatory particle

6 of 14

2.69

6.24

8.27e-13

GOCC:0008540

Proteasome regulatory particle, base subcomplex

5 of 10

2.76

5.34

7.67e-11

GOCC:0005839

Proteasome core complex

2 of 15

2.18

1.06

0.0106

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0888

Threonine protease

2 of 12

2.28

0.98

0.0153

KW-0647

Proteasome

2 of 13

2.24

0.98

0.0153

KW-0067

ATP-binding

4 of 304

1.18

0.73

0.0153

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005937

26S proteasome regulatory subunit P45-like

4 of 6

2.88

3.64

1.92e-07

IPR003960

ATPase, AAA-type, conserved site

4 of 20

2.36

2.76

4.82e-06

IPR032501

Proteasomal ATPase OB C-terminal domain

3 of 5

2.84

2.5

2.68e-05

IPR003959

ATPase, AAA-type, core

4 of 49

1.97

2.04

6.56e-05

IPR041569

AAA ATPase, AAA+ lid domain

3 of 15

2.36

1.97

0.00019

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00382

ATPases associated with a variety of cellular activities

4 of 120

1.58

1.34

0.00094

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

2 of 13

2.24

1.03

0.0121

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