STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
A0A4Y7TP56Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (943 aa)    
Predicted Functional Partners:
A0A4Y7RYY9
DNA_mis_repair domain-containing protein.
    
 0.931
A0A4Y7SPK6
DNA mismatch repair protein MutL.
    
 0.931
A0A4Y7SBS9
DNA mismatch repair protein MutL.
    
 0.866
A0A4Y7SVN4
DNA mismatch repair protein MutL.
    
 0.866
A0A4Y7SX07
MutL_C domain-containing protein.
    
 0.866
A0A4Y7SKP8
ERCC4 domain-containing protein.
    
 0.820
A0A4Y7TGC6
DRMBL-domain-containing protein.
    
 0.817
SLX1
Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.
   
 
 0.808
A0A4Y7TWW0
Asparaginyl-tRNA synthetase.
   
 
 0.793
A0A4Y7TXF0
DNA repair protein rad10.
     
 0.787
Your Current Organism:
Coprinellus micaceus
NCBI taxonomy Id: 71717
Other names: C. micaceus, Coprinus micaceus
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.