STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EFM11782.1PFAM: bifunctional deaminase-reductase domain protein; KEGG: gym:GYMC10_3222 bifunctional deaminase-reductase domain protein. (191 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.933
EFM12946.1
PFAM: homocysteine S-methyltransferase; methylenetetrahydrofolate reductase; KEGG: pjd:Pjdr2_3767 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein.
    
 0.791
EFM12084.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.734
EFM09950.1
PFAM: dihydrodipicolinate reductase; KEGG: pjd:Pjdr2_4632 NAD-dependent epimerase/dehydratase.
  
    0.706
EFM12967.1
PFAM: transcription activator effector binding; KEGG: aoe:Clos_2726 transcription activator effector binding.
   
    0.704
EFM10530.1
KEGG: gym:GYMC10_5549 RNA polymerase, sigma 28 subunit, FliA/WhiG subfamily; TIGRFAM: RNA polymerase sigma factor, sigma-70 family; PFAM: sigma-70 region 4 domain protein; sigma-70 region 2 domain protein; sigma-70 region 3 domain protein.
   
    0.704
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
   
 
 0.702
EFM09294.1
KEGG: pjd:Pjdr2_4428 FolC bifunctional protein; TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein; Belongs to the folylpolyglutamate synthase family.
     
 0.702
EFM13145.1
PFAM: iron-containing alcohol dehydrogenase; KEGG: pjd:Pjdr2_3368 iron-containing alcohol dehydrogenase.
   
    0.697
EFM08417.1
PFAM: GCN5-related N-acetyltransferase; KEGG: gym:GYMC10_5268 GCN5-related N-acetyltransferase.
   
    0.689
Your Current Organism:
Paenibacillus curdlanolyticus
NCBI taxonomy Id: 717606
Other names: P. curdlanolyticus YK9, Paenibacillus curdlanolyticus ATCC 51898, Paenibacillus curdlanolyticus DSM 10247, Paenibacillus curdlanolyticus IFO 15724, Paenibacillus curdlanolyticus NBRC 15724, Paenibacillus curdlanolyticus YK9, Paenibacillus curdlanolyticus str. YK9, Paenibacillus curdlanolyticus strain YK9
Server load: low (8%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.