STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
tdhL-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family. (345 aa)    
Predicted Functional Partners:
kbl
2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
 0.982
ilvA
Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
 0.910
ADZ89975.1
TIGRFAM: Threonine synthase; KEGG: mmw:Mmwyl1_3764 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
     
 0.902
tdh-2
L-threonine 3-dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2- amino-3-ketobutyrate; Belongs to the zinc-containing alcohol dehydrogenase family.
 
  
0.902
ADZ89614.1
Threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
     
 0.901
ADZ90231.1
Amino acid adenylation domain protein; SMART: Polyketide synthase, phosphopantetheine-binding; TIGRFAM: Amino acid adenylation; KEGG: pfs:PFLU3223 putative non-ribosomal peptide synthetase; PFAM: AMP-dependent synthetase/ligase; Condensation domain; Phosphopantetheine-binding.
     
 0.691
ADZ90946.1
KEGG: mmw:Mmwyl1_2758 sarcosine oxidase subunit alpha family protein; TIGRFAM: Sarcosine oxidase, alpha subunit, heterotetrameric; PFAM: Glycine cleavage T-protein, N-terminal; Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal; Glycine cleavage T-protein, C-terminal barrel; Belongs to the GcvT family.
  
  
 0.595
ADZ90508.1
Magnesium chelatase; PFAM: ATPase, AAA-5; KEGG: mmw:Mmwyl1_3380 magnesium chelatase; SMART: ATPase, AAA+ type, core.
   
  
 0.557
bioF
8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
  
 0.497
gcvP
Glycine dehydrogenase (decarboxylating); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.487
Your Current Organism:
Marinomonas mediterranea
NCBI taxonomy Id: 717774
Other names: M. mediterranea MMB-1, Marinomonas mediterranea MMB-1, Marinomonas mediterranea str. MMB-1, Marinomonas mediterranea strain MMB-1
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